Blockage of the NLRP3 inflammasome by MCC950 improves anti-tumor immune responses in head and neck squamous cell carcinoma

The NLRP3 inflammasome is a critical innate immune pathway responsible for producing active interleukin (IL)-1β, which is associated with tumor development and immunity. However, the mechanisms regulating the inflammatory microenvironment, tumorigenesis and tumor immunity are unclear. Herein, we show that the NLRP3 inflammasome was over-expressed in human HNSCC tissues and that the IL-1β concentration was increased in the peripheral blood of HNSCC patients. Additionally, elevated NLRP3 inflammasome levels were detected in tumor tissues of Tgfbr1/Pten 2cKO HNSCC mice, and elevated IL-1β levels were detected in the peripheral blood serum, spleen, draining lymph nodes and tumor tissues. Blocking NLRP3 inflammasome activation using MCC950 remarkably reduced IL-1β production in an HNSCC mouse model and reduced the numbers of myeloid-derived suppressor cells (MDSCs), regulatory T cells (Tregs) and tumor-associated macrophages (TAMs). Moreover, inhibiting NLRP3 inflammasome activation increased the numbers of CD4⁺ and CD8⁺ T cells in HNSCC mice. Notably, the numbers of exhausted PD-1⁺ and Tim3⁺ T cells were significantly reduced. A human HNSCC tissue microarray showed that NLRP3 inflammasome expression was correlated with the expression of CD8 and CD4, the Treg marker Foxp3, the MDSC markers CD11b and CD33, and the TAM markers CD68 and CD163, PD-1 and Tim3. Overall, our results demonstrate that the NLRP3 inflammasome/IL-1β pathway promotes tumorigenesis in HNSCC and inactivation of this pathway delays tumor growth, accompanied by decreased immunosuppressive cell accumulation and an increased number of effector T cells. Thus, inhibition of the tumor microenvironment through the NLRP3 inflammasome/IL-1β pathway may provide a novel approach for HNSCC therapy.     

Study on the Centralization Strategy of the Blood Allocation Among Different Departments within a Hospital

By far, the researches on how to distribute blood products among different departments in hospital have not been further studied, though the problem of blood shortage and wastage that caused by improper blood allocation is severe, which may endanger patient’s lives and impose considerable costs on hospitals. In order to solve this problem, this paper mainly studies on how to distribute the blood items among different departments within a hospital and investigates the allocation approach with the novel management method by centralizing the inventory of several different departments. By integrating the blood inventory requirements of some departments, the hospital could reduce the rate of blood shortage and wastage effectively, release the pressure of the occupancy of resources and reduce the bullwhip effect of blood products. This paper illustrates the centralization principle in hospital and formulates the mixed integer programming model to work out the optimal allocation network scheme and the optimal inventory setting for every department. And the results of the numerical example demonstrate that this centralization method could considerably reduce blood shortage and wastage in hospital by about 72% and 90% respectively. Furthermore, it could decrease the total cost by about 108,540 RMB a month on blood supply chain management in the hospital and improve the effect of some certain surgeries by transfusing the fresh blood to patients.     

广西高技术产业科技创新能力评价研究

文章在分析广西高技术产业发展现状基础上,构建高技术产业科技创新能力评价指标体系,运用熵值法,基于2015—2019年面板数据对广西高技术产业的创新能力进行实证研究.研究表明:广西高技术产业创新能力在西部五省中处于较低水平;广西高技术创新产出实力略低于创新投入实力,创新技术吸收实力仍相对较弱;广西高技术四大行业创新能力存在差异,即电子及通信设备制造产业科技创新投入和产出效果最好,医药制造业和电子通信及装备制造业创新投入高,创新产出评分偏低,医疗仪器设备及仪器仪表制造产业和计算机及办公设备制造产业创新吸收能力很弱.基于以上结论,文章从加大创新资源投入、推动创新平台建设、加强人才队伍建设等方面提出了对策建议.     

关于三网合一技术

介绍了我国现阶段并存的三网(电信网、有线电视网和计算机互联网)的特点与现状，分析了三网在融合过程中需要解决的一些不可避免的问题，以及三网合一的技术基础和促进三网合一的有利因素，提出了三网合一是现代通信和计算机网络发展的必然趋势，以及在三网融合的过程中还将有一个相互渗透交叉、相互竞争、共存发展过程的观点。     

Ⅰ级洁净手术室中无影灯直径的确定

采用高雷诺数K-ε二方程模型，从控制污染物的扩散范围和保证工作区乱流度这两个指标出发，对I级洁净手术室内无影灯直径进行了研究，为无影灯直径的选型提供了依据。     

尾水管水力振动的监测与故障判断

从模型及真机试验结果出发，叙述混流式水轮机一般的水力故障形式，研究了尾水管的水力振动特点及振动随运行工况而变化的情况，介绍了以压力脉动频率及幅值作为特征参量对尾水管进行振动监测及故障判断的方法。     

酸性硅溶胶沉淀法制备超微细活性白炭黑

对酸性硅溶胶沉淀法生产超微细活性白炭黑的工艺进行了研究；探讨了生产过程中硅溶胶的ｐＨ值，反应终点ｐＨ值，反应温度以及分散剂等条件；制备了较高品质的产品，其性能接近或超过国外同类产品．     

合成烯丙基砜的新方法

报道一种简单、便利的一步合成烯丙基砜的新方法。     

C60偶联多孔硅系统的蓝光发射

用G60作为表面钝化剂，与多孔硅进行偶联．发现当C60偶联多孔硅系统在空气中存储一年后，能够发射460nm左右的强烈蓝光．经过系统的测量和分析，认为蓝光起源的发光中心与SiO2体材料中的“自捕获激子”模型类似．它是由一个氧空位和一个间隙氧组成的，间隙氧同时和相邻的晶格氧形成过氧连接．光激发载流子来自于Si纳米晶粒的核心，辐射复合过程则在多孔硅表面的发光中心进行．进一步的电子束辐照和臭氧辐照实验证明了这个发光中心的存在．从FTIR谱的分析，推测是样品表面Si=O双键的缓慢变化促使了蓝光中心的自发产生．     

荧光光谱法对中药注射液热稳定性的研究

首次采用荧光光谱法对中药注射液热稳定性进行初步探讨.发现在恒温(40℃、80℃)条件下、不同中药注射液随时间变化的荧光强度和荧光光谱图,呈现出规律性的变化.通过对其谱图和荧光强度的分析,能够反映出恒温(40℃、80℃)条件下,随时间变化的荧光光谱的差异,不同温度对谱峰强度的差异性影响及不同注射剂热稳定性变化曲线的差异.找出了不同温度下不同中药注射液荧光强度减弱10%的时间.